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Article

CD2-associated protein and glomerular disease.

Lancet (London, England) - 22 Nov 2003

Wolf Gunter, Stahl Rolf A K

Abstract excerpt

CONTEXT: Proteinuria is a major cause of progression in renal disease. The glomerular ultrafiltration barrier, containing highly differentiated podocytes, normally restricts protein access to the urine. Patients with urinary protein in the nephrotic range (>3.5 g daily) often have effaced podocyt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14643126
DOI: 10.1016/S0140-6736(03)14856-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14643126-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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CD2-associated protein and glomerular disease.PMID 14643126Read ↗

CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.Semantic proximity Read ↗

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.Semantic proximity Read ↗

CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS).Semantic proximity Read ↗

CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency.Semantic proximity Read ↗

CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.Semantic proximity Read ↗

Focal segmental glomerulosclerosis in a patient homozygous for a CD2AP mutation.Semantic proximity Read ↗

Interaction of Endogenous Nephrin and CD2-Associated Protein in Mouse Epithelial M-1 Cell LineSemantic proximity Read ↗

Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis.Semantic proximity Read ↗

CD2AP and p130Cas localize to different F-actin structures in podocytesSemantic proximity Read ↗

Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot processSemantic proximity Read ↗

CD2AP is associated with end-stage renal disease in patients with type 1 diabetes.Semantic proximity Read ↗

Basic science meets clinical medicine: identification of a CD2AP-deficient patient.Semantic proximity Read ↗

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