Article
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling.
Journal of the American Society of Nephrology : JASN - 1 Oct 2010
Sison Karen, Eremina Vera, Baelde Hans, Min Wang, Hirashima Masanori, Fantus I George, Quaggin Susan E
Abstract excerpt
VEGF is a potent vascular growth factor produced by podocytes in the developing and mature glomerulus. Specific deletion of VEGF from podocytes causes glomerular abnormalities including profound endothelial cell injury, suggesting that paracrine signaling is critical for maintaining the glomerular filtration barrier (GFB). However, it is not clear whether normal GFB function also requires autocrine VEGF signaling...
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