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Article

Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.

Kidney international - 1 Jun 2014

George Britta, Fan Qingfeng, Dlugos Christopher P, Soofi Abdulsalam A, Zhang Jidong, Verma Rakesh, Park Tae-Ju, Wong Hetty, Curran Tom, Nihalani Deepak, Holzman Lawrence B

Abstract excerpt

Activation of the slit diaphragm protein nephrin induces actin cytoskeletal remodeling, resulting in lamellipodia formation in podocytes in vitro in a phosphatidylinositol-3 kinase-, focal adhesion kinase-, Cas-, and Crk1/2-dependent fashion. In mice, podocyte-specific deletion of Crk1/2 prevents...

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Identifiers

PMID: 24499776
DOI: 10.1038/ki.2013.556
PMCID: PMC4040156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24499776-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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