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Article

Interaction of Endogenous Nephrin and CD2-Associated Protein in Mouse Epithelial M-1 Cell Line

1 Jul 2002

Abstract excerpt

The interpodocyte slit diaphragm is an essential structure for maintaining the functional glomerular filtration barrier. The slit diaphragm is proposed to consist of an interacting meshwork of nephrin molecules. Earlier studies with tagged proteins have suggested that the intracellular part of nephrin interacts with CD2-associated protein (CD2AP). This study was addressed to show by coimmunoprecipitation and...

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Share to Biomedical Research and Pathophysiology
Share to Chronic Kidney Disease and Diabetes
Share to Renal Diseases and Glomerulopathies

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Identifiers

PMID: 12089372
DOI: 10.1097/01.asn.0000019842.50870.41

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Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of Endogenous Nephrin and CD2-Associated Protein in Mouse Epithelial M-1 Cell LinePMID 12089372Read ↗

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CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.Semantic proximity Read ↗

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A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytesSemantic proximity Read ↗

An update: the role of Nephrin inside and outside the kidneySemantic proximity Read ↗

CIN85/RukL Is a Novel Binding Partner of Nephrin and Podocin and Mediates Slit Diaphragm Turnover in PodocytesSemantic proximity Read ↗

Nephrin-signature molecule of the glomerular podocyte?Semantic proximity Read ↗

CD2AP and p130Cas localize to different F-actin structures in podocytesSemantic proximity Read ↗

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.Semantic proximity Read ↗

Nephrin is specifically located at the slit diaphragm of glomerular podocytes.Semantic proximity Read ↗

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

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