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Article

Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome.

Journal of the American Society of Nephrology : JASN - 1 Mar 2007

Schumacher Valérie Anne, Jeruschke Stefanie, Eitner Frank, Becker Jan Ulrich, Pitschke Gerald, Ince Yasemin, Miner Jeffrey H, Leuschner Ivo, Engers Rainer, Everding Anne Schulze, Bulla Monika, Royer-Pokora Brigitte

Abstract excerpt

Individuals with Denys-Drash syndrome (DDS) develop diffuse mesangial sclerosis, ultimately leading to renal failure. The disease is caused by mutations that affect the zinc finger structure of the Wilms' tumor protein (WT1), but the mechanisms whereby these mutations result in glomerulosclerosis remain largely obscure. How WT1 regulates genes is likely to be complex, because it has multiple splice forms, binds...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17267748
DOI: 10.1681/ASN.2006020124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome.PMID 17267748Read ↗

Exploring the Multifaceted Role of WT1 in Kidney Development and DiseaseSemantic proximity Read ↗

The role of VEGF-A in glomerular development and functionSemantic proximity Read ↗

Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis.Semantic proximity Read ↗

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.Semantic proximity Read ↗

Novel WT1 and ACTN4 co-mutations in a patient with Denys-Drash syndrome and an atypical, potentially attenuated presentation of nephropathy: a case report.Semantic proximity Read ↗

A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development.Semantic proximity Read ↗

New insights into the function of the Wilms tumor suppressor geneWT1in podocytesSemantic proximity Read ↗

Hemolytic uremic syndrome as the presenting manifestation of WT1 mutation and Denys-Drash syndrome: a case report.Semantic proximity Read ↗

Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins.Semantic proximity Read ↗

Mother-to-child transmitted WT1 splice-site mutation is responsible for distinct glomerular diseases.Semantic proximity Read ↗

WT1 and PAX-2 Podocyte Expression in Denys-Drash Syndrome and Isolated Diffuse Mesangial SclerosisSemantic proximity Read ↗

Focal Segmental Membranoproliferative Glomerulonephritis: A Histological Variant of Denys-Drash Syndrome.Semantic proximity Read ↗

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