Article
Emilin1 links TGF-beta maturation to blood pressure homeostasis.
Cell - 10 Mar 2006
Zacchigna Luca, Vecchione Carmine, Notte Antonella, Cordenonsi Michelangelo, Dupont Sirio, Maretto Silvia, Cifelli Giuseppe, Ferrari Alessandra, Maffei Angelo, Fabbro Carla, Braghetta Paola, Marino Gennaro, Selvetella Giulio, Aretini Alessandra, Colonnese Claudio, Bettarini Umberto, Russo Giovanni, Soligo Sandra, Adorno Maddalena, Bonaldo Paolo, Volpin Dino, Piccolo Stefano, Lembo Giuseppe, Bressan Giorgio M
Abstract excerpt
TGF-beta proteins are main regulators of blood vessel development and maintenance. Here, we report an unprecedented link between TGF-beta signaling and arterial hypertension based on the analysis of mice mutant for Emilin1, a cysteine-rich secreted glycoprotein expressed in the vascular tree. Emilin1 knockout animals display increased blood pressure, increased peripheral vascular resistance, and reduced vessel...
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