Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 Nef-mediated T-cell activation and chemotaxis are decoupled using a HIV-1/SIVpbj1.9. chimeric nef variant.

Archives of virology - 1 Apr 2013

Park In-Woo, He Johnny J

Abstract excerpt

HIV-1 Nef is known to activate CD4+ T cells but inhibit their migration toward SDF-1α. However, it is not clear how this protein orchestrates these two seemingly concomitant events. In this study, by comparing these two activities of HIV-1 Nef with those of its primate counterpart, SIVpbj1.9, we found that HIV-1 Nef activated T cells only in the presence of CD3/ CD28 stimulation, while SIVpbj1.9 Nef did even...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD28 Antigens
Share to CD3 Complex
Share to Chemotaxis, Leukocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Interleukin-2

Share to Jurkat Cells

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Simian Immunodeficiency Virus

Source

Identifiers

PMID: 23224761
DOI: 10.1007/s00705-012-1560-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 Nef-mediated T-cell activation and chemotaxis are decoupled using a HIV-1/SIVpbj1.9. chimeric nef variant.PMID 23224761Read ↗

HIV-1 Nef-mediated inhibition of T cell migration and its molecular determinants.Semantic proximity Read ↗

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling.Semantic proximity Read ↗

HIV ‐1 Nef: Taking Control of Protein TraffickingSemantic proximity Read ↗

How HIV Nef Proteins Hijack Membrane Traffic To Promote InfectionSemantic proximity Read ↗

Functional characterization of HIV-1 Nef mutants in the context of viral infection.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking PathwaysSemantic proximity Read ↗

Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development.Semantic proximity Read ↗

Lentiviral Nef Proteins Utilize PAK2-Mediated Deregulation of Cofilin as a General Strategy To Interfere with Actin RemodelingSemantic proximity Read ↗

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5Semantic proximity Read ↗

Interactions of HIV-1 NEF with cellular signal transducing proteinsSemantic proximity Read ↗

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5Semantic proximity Read ↗

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.