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Article

Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor.

Proteins - 1 Mar 2011

Nikiforovich Gregory V, Marshall Garland R, Baranski Thomas J

Abstract excerpt

Molecular modeling of conformational changes occurring in the transmembrane region of the complement factor 5a receptor (C5aR) during receptor activation was performed by comparing two constitutively active mutants (CAMs) of C5aR, NQ (I124N/L127Q), and F251A, to those of the wild-type C5aR and NQ-N296A (I124N/L127Q/N296A), which have the wild-type phenotype. Modeling involved comprehensive sampling of various...

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PMID: 21287612
DOI: 10.1002/prot.22918
PMCID: PMC3072438

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