Article
The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Dec 2012
Haag Natja, Schwintzer Lukas, Ahuja Rashmi, Koch Nicole, Grimm Julia, Heuer Heike, Qualmann Britta, Kessels Michael M
Abstract excerpt
Cortical actin dynamics shapes cells. To generate actin filaments, cells rely on actin nucleators. Cobl is a novel, brain-enriched, WH2 domain-based actin nucleator, yet, its functions remained largely elusive. Here, we reveal that Cobl plays a crucial role in Purkinje cell development using gene gun transfections within intact murine cerebellar contexts. Cobl deficiency impaired proper dendritic arborization of...
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