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Article

Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†.

Human molecular genetics - 1 Apr 2016

Mukherjee Kusumika, Ishii Kana, Pillalamarri Vamsee, Kammin Tammy, Atkin Joan F, Hickey Scott E, Xi Qiongchao J, Zepeda Cinthya J, Gusella James F, Talkowski Michael E, Morton Cynthia C, Maas Richard L, Liao Eric C

Abstract excerpt

CAPZB is an actin-capping protein that caps the growing end of F-actin and modulates the cytoskeleton and tethers actin filaments to the Z-line of the sarcomere in muscles. Whole-genome sequencing was performed on a subject with micrognathia, cleft palate and hypotonia that harbored a de novo, balanced chromosomal translocation that disrupts the CAPZB gene. The function of capzb was analyzed in the zebrafish...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26758871
DOI: 10.1093/hmg/ddw006
PMCID: PMC4787901

Genes

CAPZB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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