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Article

Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly.

EMBO reports - 1 Jan 2026

Niehaus Indra, Wilsch-Bräuninger Michaela, Mora-Bermúdez Felipe, Rost Fabian, Bobic-Rasonja Mihaela, Radosevic Velena, Milkovic-Perisa Marija, Wimberger Pauline, Severino Mariasavina, Haase Alexandra, Martin Ulrich, Kuenzel Karolina, Guan Kaomei, Neumann Katrin, Walker Noreen, Schröck Evelin, Jovanov-Milosevic Natasa, Huttner Wieland B, Di Donato Nataliya, Heide Michael

Abstract excerpt

Actins are cytoskeletal proteins that are essential for multiple cellular processes. Mutations in the ACTB and ACTG1 genes, encoding the ubiquitous beta- and gamma-cytoskeletal actin isoforms, respectively, cause a broad spectrum of neurodevelopmental disorders, with microcephaly as the most frequent one. To investigate the pathogenesis underlying this cortical malformation, we studied patient-derived cerebral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41372632
DOI: 10.1038/s44319-025-00647-7
PMCID: PMC12852704

Genes

ACTB
ACTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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