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Article

The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.

The Journal of biological chemistry - 25 Jan 2013

Kang Kyungjoon, Lee Donghoon, Hong Seulgi, Park Sung-Gyoo, Song Mi-Ryoung

Abstract excerpt

The Notch signaling pathway is essential for neuronal and glial specification during CNS development. Mind bomb-1 (Mib1) is an E3 ubiquitin ligase that ubiquitinates and promotes the endocytosis of Notch ligands. Although Mib1 is essential for transmitting the Notch signal, it is still unclear whether it is a primary regulator of Notch ligand activity in the developing spinal cord. In Mib1 conditional knock-out...

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Identifiers

PMID: 23223237
DOI: 10.1074/jbc.M112.398263
PMCID: PMC3554925

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The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.PMID 23223237Read ↗

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The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.Semantic proximity Read ↗

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