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Article

Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.

Molecular brain - 30 Oct 2012

Yoon Ki-Jun, Lee Hye-Ryeon, Jo Yong Sang, An Kyongman, Jung Sang-Yong, Jeong Min-Woo, Kwon Seok-Kyu, Kim Nam-Shik, Jeong Hyun-Woo, Ahn Seo-Hee, Kim Kyong-Tai, Lee Kyungmin, Kim Eunjoon, Kim Joung-Hun, Choi June-Seek, Kaang Bong-Kiun, Kong Young-Yun

Abstract excerpt

BACKGROUND: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the...

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Identifiers

PMID: 23111145
DOI: 10.1186/1756-6606-5-40
PMCID: PMC3541076

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