Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mind bomb-2 is an E3 ligase for Notch ligand.

The Journal of biological chemistry - 10 Jun 2005

Koo Bon-Kyoung, Yoon Ki-Jun, Yoo Kyeong-Won, Lim Hyoung-Soo, Song Ran, So Ju-Hoon, Kim Cheol-Hee, Kong Young-Yun

Abstract excerpt

The zebrafish gene, mind bomb (mib), encodes a protein that positively regulates of the Delta-mediated Notch signaling. It interacts with the intracellular domain of Delta to promote its ubiquitination and endocytosis. In our search for the mouse homologue of zebrafish mind bomb, we cloned two homologues in the mouse genome: a mouse orthologue (mouse mib1) and a paralogue, named mind bomb-2 (mib2), which is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Immunoprecipitation
Share to In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Notch

Share to Subcellular Fractions

Share to Ubiquitin

Share to Xenopus

Share to Zebrafish Proteins

Source

Identifiers

PMID: 15824097
DOI: 10.1074/jbc.M501631200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mind bomb-2 is an E3 ligase for Notch ligand.PMID 15824097Read ↗

Transcriptome analysis of the zebrafish mind bomb mutant.Semantic proximity Read ↗

Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.Semantic proximity Read ↗

An obligatory role of mind bomb-1 in notch signaling of mammalian development.Semantic proximity Read ↗

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.Semantic proximity Read ↗

The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly.Semantic proximity Read ↗

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.Semantic proximity Read ↗

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.Semantic proximity Read ↗

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.Semantic proximity Read ↗

Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes.Semantic proximity Read ↗

The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.Semantic proximity Read ↗

Identification of the essential protein domains for Mib2 function during the development of the Drosophila larval musculature and adult flight muscles.Semantic proximity Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.