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Article

The fidelity of transcription: RPB1 (RPO21) mutations that increase transcriptional slippage in S. cerevisiae.

The Journal of biological chemistry - 25 Jan 2013

Strathern Jeffrey, Malagon Francisco, Irvin Jordan, Gotte Deanna, Shafer Brenda, Kireeva Maria, Lubkowska Lucyna, Jin Ding Jun, Kashlev Mikhail

Abstract excerpt

The fidelity of RNA synthesis depends on both accurate template-mediated nucleotide selection and proper maintenance of register between template and RNA. Loss of register, or transcriptional slippage, is particularly likely on homopolymeric runs in the template. Transcriptional slippage can alter the coding capacity of mRNAs and is used as a regulatory mechanism. Here we describe mutations in the largest subunit...

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Identifiers

PMID: 23223234
DOI: 10.1074/jbc.M112.429506
PMCID: PMC3554935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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