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Article

Nondisjunctional segregations in Drosophila female meiosis I are preceded by homolog malorientation at metaphase arrest.

Genetics - 1 Feb 2013

Gillies Shane C, Lane Fiona M, Paik Wonbeom, Pyrtel Khateriaa, Wallace Nneka T, Gilliland William D

Abstract excerpt

The model of Drosophila female meiosis I was recently revised by the discovery that chromosome congression precedes metaphase I arrest. Use of the prior framework to interpret data from meiotic mutants led to the conclusion that chromosome segregation errors (nondisjunction, NDJ) occurred when nonexchange chromosomes moved out on the spindle in a maloriented configuration and became trapped there at metaphase...

Topics

Animals
Cell Cycle Proteins
Chromosome Segregation
Chromosomes, Insect
Drosophila
Drosophila Proteins
Female
Kinesins
Meiosis
Metaphase
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nondisjunction, Genetic

Protein Serine-Threonine Kinases

Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 23222652
DOI: 10.1534/genetics.112.146241
PMCID: PMC3567735

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