A cytological F1 RNAi screen for defects in Drosophila melanogaster female meiosis.

doi:10.1093/genetics/iyae046

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Article

A cytological F1 RNAi screen for defects in Drosophila melanogaster female meiosis.

Genetics - 7 May 2024

Gilliland William D, May Dennis P, Bowen Amelia O, Conger Kelly O, Elrad Doreen, Marciniak Marcin, Mashburn Sarah A, Presbitero Gabrielle, Welk Lucas F

Abstract excerpt

Genetic screens for recessive alleles induce mutations, make the mutated chromosomes homozygous, and then assay those homozygotes for the phenotype of interest. When screening for genes required for female meiosis, the phenotype of interest has typically been nondisjunction from chromosome segregation errors. As this requires that mutant females be viable and fertile, any mutants that are lethal or sterile when...

Topics

Animals
Female
Meiosis
Drosophila melanogaster
RNA Interference
Phenotype
Oocytes
Drosophila Proteins
Genetic Testing

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Identifiers

PMID: 38531678
DOI: 10.1093/genetics/iyae046
PMCID: PMC11075555

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