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Article

IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention: the POUNDS LOST trial.

Diabetes care - 1 Nov 2013

Qi Qibin, Xu Min, Wu Hongyu, Liang Liming, Champagne Catherine M, Bray George A, Sacks Frank M, Qi Lu

Abstract excerpt

OBJECTIVE: Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial. RESEARCH DESIGN AND METHODS: Two variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24009303
DOI: 10.2337/dc13-0018
PMCID: PMC3816909

Genes

IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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