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Article

Comparison of P-glycoprotein function in peripheral blood mononuclear cells ex vivo in stable Black and White male and female kidney transplant recipients.

Clinical and translational science - 1 Feb 2023

Tornatore Kathleen M, Attwood Kris, Brazeau Daniel, Sprowl Jason, Chang Shirley, Gundroo Aijaz, Minderman Hans, Venuto Rocco C

Abstract excerpt

Kidney allograft survival remains poorer in Black compared to White recipients due to racial differences in calcineurin inhibitor (CNI) pharmacology. P-glycoprotein (P-gp), an ABC efflux transporter expressed in peripheral blood mononuclear cells (PBMCs), modulates CNI pharmacokinetics and intracellular pharmacology. This study investigated P-gp function in PBMC ex vivo at 0 (trough), 4, 8, and 12 h in stable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36352830
DOI: 10.1111/cts.13444
PMCID: PMC9926080

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