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Article

Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients.

Clinical pharmacokinetics - 1 Sept 2013

Ogasawara Ken, Chitnis Shripad D, Gohh Reginald Y, Christians Uwe, Akhlaghi Fatemeh

Abstract excerpt

BACKGROUND AND OBJECTIVE: Tacrolimus is an immunosuppressive drug used for the prevention of the allograft rejection in kidney transplant recipients. It exhibits a narrow therapeutic index and large pharmacokinetic variability. Tacrolimus is mainly metabolized by cytochrome P450 (CYP) 3A4 and 3A5 and effluxed via ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp), encoded by ABCB1 gene. The...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Share to Cytochrome P-450 CYP3A

Share to Immunosuppressive Agents

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

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Source

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Identifiers

PMID: 23633119
DOI: 10.1007/s40262-013-0069-2
PMCID: PMC3755037

Genes

ABCC2
ABCB1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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