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Use of Pharmacogenetics to Optimize Immunosuppressant Therapy in Kidney-Transplanted Patients

26 Jul 2022

Abstract excerpt

Immunosuppressant drugs (ISDs) are routinely used in clinical practice to maintain organ transplant survival. However, these drugs are characterized by a restricted therapeutic index, a high inter- and intra-individual pharmacokinetic variability, and a series of severe adverse effects. In particular, genetic factors have been estimated to play a role in this variability because of polymorphisms regarding genes...

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PMID: 35892699
DOI: 10.3390/biomedicines10081798

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