Article
Influence of MRP2 on MPA pharmacokinetics in renal transplant recipients-results of the Pharmacogenomic Substudy within the Symphony Study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Nov 2011
Lloberas Nuria, Torras Juan, Cruzado Josep Ma, Andreu Franc, Oppenheimer Federico, Sánchez-Plumed Jaime, Gentil Miguel Ángel, Brunet Mercé, Ekberg Henrik, Grinyó Josep M
Abstract excerpt
BACKGROUND: The aim of this study was to determine the relationship between single-nucleotide polymorphisms (SNPs) in MRP2 genes and mycophenolic acid (MPA) pharmacokinetics in renal transplant recipients of the Symphony Pharmacogenomic substudy. METHODS: Sixty-six renal transplant recipients of eight Spanish centres were randomized into four branches of immunosuppressive regimen: low dose of cyclosporine,...
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