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Article

Effect of NQO1 and CYP4F2 genotypes on warfarin dose requirements in Hispanic-Americans and African-Americans.

Pharmacogenomics - 1 Dec 2012

Bress Adam, Patel Shitalben R, Perera Minoli A, Campbell Richard T, Kittles Rick A, Cavallari Larisa H

Abstract excerpt

AIM: The objective of this study was to determine the additional contribution of NQO1 and CYP4F2 genotypes to warfarin dose requirements across two racial groups after accounting for known clinical and genetic predictors. PATIENTS & METHODS: The following were assessed in a cohort of 260 African-Americans and 53 Hispanic-Americans: clinical data; NQO1 p.P187S (*1/*2); CYP2C9*2, *3, *5, *6, *8 and *11; CYP4F2...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Cytochrome P450 Family 4

Share to Dose-Response Relationship, Drug

Share to Hispanic or Latino

Share to NAD(P)H Dehydrogenase (Quinone)

Share to Warfarin

Source

Open in PubMed Open full text

Identifiers

PMID: 23215885
DOI: 10.2217/pgs.12.164
PMCID: PMC3586586

Genes

NQO1
VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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