Article
Race influences warfarin dose changes associated with genetic factors.
Blood - 23 Jul 2015
Limdi Nita A, Brown Todd M, Yan Qi, Thigpen Jonathan L, Shendre Aditi, Liu Nianjun, Hill Charles E, Arnett Donna K, Beasley T Mark
Abstract excerpt
Warfarin dosing algorithms adjust for race, assigning a fixed effect size to each predictor, thereby attenuating the differential effect by race. Attenuation likely occurs in both race groups but may be more pronounced in the less-represented race group. Therefore, we evaluated whether the effect of clinical (age, body surface area [BSA], chronic kidney disease [CKD], and amiodarone use) and genetic factors...
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