Article
The importance of serine 776 in Ataxin-1 partner selection: a FRET analysis.
Scientific reports - 1 Jan 2012
Menon Rajesh P, Soong Daniel, de Chiara Cesira, Holt Mark R, Anilkumar Narayana, Pastore Annalisa
Abstract excerpt
Anomalous expansion of a polymorphic tract in Ataxin-1 causes the autosomal dominant spinocerebellar ataxia type 1. In addition to polyglutamine expansion, requirements for development of pathology are phosphorylation of serine 776 in Ataxin-1 and nuclear localization of the protein. The phosphor...
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