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Article

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.

The Biochemical journal - 1 Jul 2011

Bouskila Michale, Esoof Noor, Gay Laurie, Fang Emily H, Deak Maria, Begley Michael J, Cantley Lewis C, Prescott Alan, Storey Kate G, Alessi Dario R

Abstract excerpt

Mutations that truncate the C-terminal non-catalytic moiety of TTBK2 (tau tubulin kinase 2) cause the inherited, autosomal dominant, SCA11 (spinocerebellar ataxia type 11) movement disorder. In the present study we first assess the substrate specificity of TTBK2 and demonstrate that it has an unu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21548880
DOI: 10.1042/BJ20110276
PMCID: PMC3739326

Genes

TTBK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21548880-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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