Article
The 'evolvability' of promiscuous protein functions.
Nature genetics - 1 Jan 2005
Aharoni Amir, Gaidukov Leonid, Khersonsky Olga, McQ Gould Stephen, Roodveldt Cintia, Tawfik Dan S
Abstract excerpt
How proteins with new functions (e.g., drug or antibiotic resistance or degradation of man-made chemicals) evolve in a matter of months or years is still unclear. This ability is dependent on the induction of new phenotypic traits by a small number of mutations (plasticity). But mutations often have deleterious effects on functions that are essential for survival. How are these seemingly conflicting demands met...
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- Aryldialkylphosphatase
- Bacteria
- Carbonic Anhydrase II
- Evolution, Molecular
- Genetic Variation
- Humans
- Phosphoric Triester Hydrolases