Article
Adaptive benefits from small mutation supplies in an antibiotic resistance enzyme.
Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2017
Salverda Merijn L M, Koomen Jeroen, Koopmanschap Bertha, Zwart Mark P, de Visser J Arjan G M
Abstract excerpt
Populations with large mutation supplies adapt via the "greedy" substitution of the fittest genotype available, leading to fast and repeatable short-term responses. At longer time scales, smaller mutation supplies may in theory lead to larger improvements when distant high-fitness genotypes more readily evolve from lower-fitness intermediates. Here we test for long-term adaptive benefits from small mutation...
Topics
- Adaptation, Physiological
- Alleles
- Anti-Bacterial Agents
- Bacterial Proteins
- Cefotaxime
- Cloning, Molecular
- Directed Molecular Evolution
- Escherichia coli
- Gene Expression
- Gene Library