Dynamics and constraints of enzyme evolution.

Abstract excerpt

The wealth of distinct enzymatic functions found in nature is impressive and the on-going evolutionary divergence of enzymatic functions continues to generate new and efficient catalysts, which can be seen through the recent emergence of enzymes able to degrade xenobiotics. However, recreating such processes in the laboratory has been met with only moderate success. What are the factors that lead to suboptimal...

Topics

• Enzymes
• Epistasis, Genetic
• Evolution, Molecular
• Mutagenesis
• Mutation
• Proteins