Article
Natural history as a predictor of protein evolvability.
Protein engineering, design & selection : PEDS - 1 Oct 2006
O'Loughlin Taryn L, Patrick Wayne M, Matsumura Ichiro
Abstract excerpt
Natural selection generally produces specific and efficient enzymes. In contrast, directed evolution experiments usually produce enzyme variants with broadened substrate specificity or enhanced catalytic promiscuity. Some proteins may be more evolvable than others, but few workers consider this p...
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