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Article

Enzyme engineering: reaching the maximal catalytic efficiency peak.

Current opinion in structural biology - 1 Dec 2017

Goldsmith Moshe, Tawfik Dan S

Abstract excerpt

The practical need for highly efficient enzymes presents new challenges in enzyme engineering, in particular, the need to improve catalytic turnover (kcat) or efficiency (kcat/KM) by several orders of magnitude. However, optimizing catalysis demands navigation through complex and rugged fitness landscapes, with optimization trajectories often leading to strong diminishing returns and dead-ends. When no further...

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Source

Identifiers

PMID: 29035814
DOI: 10.1016/j.sbi.2017.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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