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Article

Evolutionary dynamics of enzymes.

Protein engineering - 1 Aug 1995

Demetrius L

Abstract excerpt

This paper codifies and rationalizes the large diversity in reaction rates and substrate specificity of enzymes in terms of a model which postulates that the kinetic properties of present-day enzymes are the consequence of the evolutionary force of mutation and selection acting on a class of prim...

Topics

Animals
Biological Evolution
Catalysis
Diploidy
Enzyme Stability
Enzymes
Haploidy
Kinetics
Mathematics
Models, Theoretical
Mutation
Selection, Genetic
Substrate Specificity
Thermodynamics

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Source

Identifiers

PMID: 8637848
DOI: 10.1093/protein/8.8.791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8637848-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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