Article
In the light of directed evolution: pathways of adaptive protein evolution.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2009
Bloom Jesse D, Arnold Frances H
Abstract excerpt
Directed evolution is a widely-used engineering strategy for improving the stabilities or biochemical functions of proteins by repeated rounds of mutation and selection. These experiments offer empirical lessons about how proteins evolve in the face of clearly-defined laboratory selection pressures. Directed evolution has revealed that single amino acid mutations can enhance properties such as catalytic activity...
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