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Article

Up-regulation of NOTCH4 gene expression in bipolar disorder.

The American journal of psychiatry - 1 Dec 2012

Dieset Ingrid, Djurovic Srdjan, Tesli Martin, Hope Sigrun, Mattingsdal Morten, Michelsen Annika, Joa Inge, Larsen Tor Ketil, Agartz Ingrid, Melle Ingrid, Røssberg Jan Ivar, Aukrust Pål, Andreassen Ole A, Ueland Thor

Abstract excerpt

OBJECTIVE: Immunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, and genome-wide association studies (GWAS) point to the major histocompatibility complex, a region that contains many immune-related genes. One of the strongest candidate risk genes for schizophreni...

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Source

Identifiers

PMID: 23212060
DOI: 10.1176/appi.ajp.2012.11091431

Genes

NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23212060-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Up-regulation of NOTCH4 gene expression in bipolar disorder.PMID 23212060Read ↗

The NOTCH4 locus is associated with susceptibility to schizophrenia.Semantic proximity Read ↗

Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene.Semantic proximity Read ↗

A re-review of the association between the NOTCH4 locus and schizophrenia.Semantic proximity Read ↗

A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia.Semantic proximity Read ↗

Transcriptome study of differential expression in schizophrenia.Semantic proximity Read ↗

Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to five autoimmune diseasesSemantic proximity Read ↗

Neither single-marker nor haplotype analyses support an association between genetic variation near NOTCH4 and bipolar disorder.Semantic proximity Read ↗

Identification of novel single nucleotide polymorphisms within the NOTCH4 gene and determination of association with MHC alleles.Semantic proximity Read ↗

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis.Semantic proximity Read ↗

Association study of Wnt signaling pathway genes in bipolar disorder.Semantic proximity Read ↗

Polymorphism of Toll-like receptor 4 gene in bipolar disorder.Semantic proximity Read ↗

Is NOTCH4 associated with schizophrenia?Semantic proximity Read ↗

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