Article
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.
Science (New York, N.Y.) - 30 Mar 1990
Liou H C, Boothby M R, Finn P W, Davidon R, Nabavi N, Zeleznik-Le N J, Ting J P, Glimcher L H
Abstract excerpt
Several mutants derived from transformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes. The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box, a conserved transcriptional element in the promoter region. A complementary DNA encoding a DNA-binding protein (human X box binding protein, hXBP-1) whose...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Cell Line, Transformed
- DNA
- DNA-Binding Proteins
- HLA-DR Antigens
- Humans
- Leucine
- Molecular Sequence Data