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Article

Carvedilol inhibits neuronal hyperexcitability caused by epilepsy-associated KCNT1 mutations.

British journal of pharmacology - 1 Jan 2025

Di Chang, Wu Tong, Gao Kai, Li Na, Song Huifang, Wang Lili, Sun Haojie, Yi Jingyun, Zhang Xinran, Chen Jiexin, Shah Mala, Jiang Yuwu, Huang Zhuo

Abstract excerpt

BACKGROUND AND PURPOSE: KCNT1 encodes a sodium-activated potassium channel (Slack channel), and its mutation can cause several forms of epilepsy. Traditional antiepileptic medications have limited efficacy in treating patients with KCNT1 mutations. Here, we describe one heterozygous KCNT1 mutation, M267T, in a patient with EIMFS. The pathological channel properties of this mutation and its effect on neuronal...

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PMID: 39370580
DOI: 10.1111/bph.17360

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