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Article

Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents.

Neuropharmacology - 1 Aug 2018

McGuier Natalie S, Rinker Jennifer A, Cannady Reginald, Fulmer Diana B, Jones Sara R, Hoffman Michaela, Mulholland Patrick J

Abstract excerpt

Currently available pharmacotherapies for treating alcohol use disorder (AUD) suffer from deleterious side effects and are not efficacious in diverse populations. Clinical and preclinical studies provide evidence that the Kcnq family of genes that encode KV7 channels influence alcohol intake and dependence. KV7 channels are a class of slowly activating voltage-dependent K+ channels that regulate neuronal...

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Identifiers

PMID: 29775679
DOI: 10.1016/j.neuropharm.2018.05.020
PMCID: PMC6054890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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