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Article

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Antimicrobial agents and chemotherapy - 1 Aug 2018

Wall Richard J, Moniz Sonia, Thomas Michael G, Norval Suzanne, Ko Eun-Jung, Marco Maria, Miles Timothy J, Gilbert Ian H, Horn David, Fairlamb Alan H, Wyllie Susan

Abstract excerpt

The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents. Here, we report the results of our orthogonal genetic, molecular, and biochemical studies to determine the MoA of a novel 7-substituted 8-hydroxy-1,6-naphthyridine (8-HNT) series that displays promising activity...

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Identifiers

PMID: 29844044
DOI: 10.1128/AAC.00235-18
PMCID: PMC6105827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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