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Article

The antimalarial drug quinine disrupts Tat2p-mediated tryptophan transport and causes tryptophan starvation.

The Journal of biological chemistry - 3 Jul 2009

Khozoie Combiz, Pleass Richard J, Avery Simon V

Abstract excerpt

Quinine is a major drug of choice for the treatment of malaria. However, the primary mode of quinine action is unclear, and its efficacy is marred by adverse reactions among patients. To help address these issues, a genome-wide screen for quinine sensitivity was carried out using the yeast deleti...

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Identifiers

PMID: 19416971
DOI: 10.1074/jbc.M109.005843
PMCID: PMC2709357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19416971-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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