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Article

Mutations in the transcription elongation factor SPT5 disrupt a reporter for dosage compensation in Drosophila.

PLoS genetics - 1 Jan 2012

Prabhakaran Mahalakshmi, Kelley Richard L

Abstract excerpt

In Drosophila, the MSL (Male Specific Lethal) complex up regulates transcription of active genes on the single male X-chromosome to equalize gene expression between sexes. One model argues that the MSL complex acts upon the elongation step of transcription rather than initiation. In an unbiased forward genetic screen for new factors required for dosage compensation, we found that mutations in the universally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23209435
DOI: 10.1371/journal.pgen.1003073
PMCID: PMC3510053

Genes

MSL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the transcription elongation factor SPT5 disrupt a reporter for dosage compensation in Drosophila.PMID 23209435Read ↗

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