Article
The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.
Development (Cambridge, England) - 1 Apr 2002
Keegan Brian R, Feldman Jessica L, Lee Diana H, Koos David S, Ho Robert K, Stainier Didier Y R, Yelon Deborah
Abstract excerpt
Precise temporal and spatial control of transcription is a fundamental component of embryonic development. Regulation of transcription elongation can act as a rate-limiting step during mRNA synthesis. The mechanisms of stimulation and repression of transcription elongation during development are not yet understood. We have identified a class of zebrafish mutations (pandora, sk8 and s30) that cause multiple...
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