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Article

A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.

PLoS genetics - 1 Jan 2012

Miller John P, Yates Bridget E, Al-Ramahi Ismael, Berman Ari E, Sanhueza Mario, Kim Eugene, de Haro Maria, DeGiacomo Francesco, Torcassi Cameron, Holcomb Jennifer, Gafni Juliette, Mooney Sean D, Botas Juan, Ellerby Lisa M, Hughes Robert E

Abstract excerpt

A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolysis, glutamate excitotoxicity, and mitochondrial dysfunction. In addition to established mechanisms, the screen identified multiple components of the RRAS signaling...

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Source

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Identifiers

PMID: 23209424
DOI: 10.1371/journal.pgen.1003042
PMCID: PMC3510027

Genes

RRAS
FNTA
PIN1
PLK1
RAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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