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Article

Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.

Nature neuroscience - 1 May 2013

Lu Boxun, Al-Ramahi Ismael, Valencia Antonio, Wang Qiong, Berenshteyn Frada, Yang Haidi, Gallego-Flores Tatiana, Ichcho Salah, Lacoste Arnaud, Hild Marc, Difiglia Marian, Botas Juan, Palacino James

Abstract excerpt

Huntington's disease is caused by expanded CAG repeats in HTT, conferring toxic gain of function on mutant HTT (mHTT) protein. Reducing mHTT amounts is postulated as a strategy for therapeutic intervention. We conducted genome-wide RNA interference screens for genes modifying mHTT abundance and identified 13 hits. We tested 10 in vivo in a Drosophila melanogaster Huntington's disease model, and 6 exhibited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23525043
DOI: 10.1038/nn.3367

Genes

NUB1
CUL3
HTT
NEDD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.PMID 23525043Read ↗

NUB1 snubs huntingtin toxicity.Semantic proximity Read ↗

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RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation.Semantic proximity Read ↗

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.Semantic proximity Read ↗

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.Semantic proximity Read ↗

The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila.Semantic proximity Read ↗

Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat BindingSemantic proximity Read ↗

HTT loss-of-function contributes to RNA deregulation in developing Huntington’s disease neuronsSemantic proximity Read ↗

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington’s disease pathogenesis in miceSemantic proximity Read ↗

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