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Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

14 Jul 2011

Abstract excerpt

BACKGROUND: The molecular phenotype of Huntington's disease (HD) is known to comprise highly reproducible changes in gene expression involving striatal signaling genes. Here we test whether individual changes in striatal gene expression are capable of mitigating HD-related neurotoxicity. METHODOLOGY/PRINCIPAL FINDINGS: We used protein-encoding and shRNA-expressing lentiviral vectors to evaluate the effects of...

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PMID: 21779398
DOI: 10.1371/journal.pone.0022231

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