Article
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.
PLoS pathogens - 1 Feb 2020
Lee Brendon M, Harold Liam K, Almeida Deepak V, Afriat-Jurnou Livnat, Aung Htin Lin, Forde Brian M, Hards Kiel, Pidot Sacha J, Ahmed F Hafna, Mohamed A Elaaf, Taylor Matthew C, West Nicholas P, Stinear Timothy P, Greening Chris, Beatson Scott A, Nuermberger Eric L, Cook Gregory M, Jackson Colin J
Abstract excerpt
Our inability to predict which mutations could result in antibiotic resistance has made it difficult to rapidly identify the emergence of resistance, identify pre-existing resistant populations, and manage our use of antibiotics to effectively treat patients and prevent or slow the spread of resistance. Here we investigated the potential for resistance against the new antitubercular nitroimidazole prodrugs...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Drug Resistance, Bacterial
- Mutation
- Mycobacterium tuberculosis
- Nitroimidazoles
- Nitroreductases
- Oxazoles
- Polymorphism, Genetic