Article
Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.
PloS one - 17 Oct 2007
Dicko Alassane, Diemert David J, Sagara Issaka, Sogoba Moussa, Niambele Mohamed B, Assadou Mahamadoun H, Guindo Ousmane, Kamate Beh, Baby Mounirou, Sissoko Mady, Malkin Elissa M, Fay Michael P, Thera Mahamadou A, Miura Kazutoyo, Dolo Amagana, Diallo Dapa A, Mullen Gregory E, Long Carole A, Saul Allan, Doumbo Ogobara, Miller Louis H
Abstract excerpt
BACKGROUND: Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses. STUDY DESIGN/RESULTS: A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria transmission to...
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