Article
The role of SCCA1 in asthma related physiological events in the airway epithelium and the effect of promoter variants on asthma and gene function.
Respiratory medicine - 1 Mar 2013
Karaaslan Cagatay, Birben Esra, Keskin Ozlem, Sahiner Umit, Sackesen Cansin, Kalayci Omer
Abstract excerpt
BACKGROUND: Even though the systemic level of SCCA1, a serine protease inhibitor, was shown to be elevated in asthma, its physiological role is unknown. OBJECTIVE: We sought to determine the effect of SCCA1 on apoptosis, cytokine expression and mucus production by A549 cells and define the effect of promoter variants on gene expression and association with asthma. METHODS: SCCA levels were measured by ELISA....
Topics
- Adolescent
- Antigens, Neoplasm
- Apoptosis
- Asthma
- Case-Control Studies
- Cells, Cultured
- Child
- Cytokines
- Eosinophils
- Female
- GATA2 Transcription Factor
- GATA3 Transcription Factor
- Gene Expression Regulation