Article
Promoter analyses of SCC antigen genes.
Biochimica et biophysica acta - 10 Mar 2005
Suminami Yoshinori, Kishi Fumio, Nawata Shugo, Murakami Akihiro, Sakaguchi Yuko, Sueoka Kotaro, Numa Fumitaka, Sugino Norihiro, Kato Hiroshi
Abstract excerpt
SCC antigen (SCCA) has been used as a tumor marker for squamous cell carcinoma. Analyses of the SCCA1 and SCCA2 genes, which are almost identical, and their promoters have been reported. Recently it was found that both SCCAs were stimulated by interleukin (IL)-4 and IL-13. Here we analyzed the promoter activity of both SCCAs in the 5'-flanking region, exon 1, and intron 1 to evaluate a putative STAT6 binding...
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