Article
Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness.
Allergy - 1 Jun 2009
Reijmerink N E, Kerkhof M, Koppelman G H, Gerritsen J, de Jongste J C, Smit H A, Brunekreef B, Postma D S
Abstract excerpt
INTRODUCTION: ADAM33 is the first identified asthma gene by positional cloning, especially asthma combined with bronchial hyperresponsiveness (BHR). Moreover, ADAM33 is associated with early-life lung function and decline of forced expiratory volume in 1 s (FEV(1)) in the general population. In utero and postnatal cigarette smoke exposure (CSE) are associated with reduced lung function, and development of BHR and...
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