Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

26 Sept 2007

Abstract excerpt

Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute to airway epithelial goblet cell metaplasia and may alter epithelial-mesenchymal signaling, leading to increased subepithelial fibrosis or hyperplasia of smooth muscle. The beneficial effects of corticosteroids in asthma could relate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to IL-33, ST2, and ILC Pathways
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17898169
DOI: 10.1073/pnas.0707413104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroidsPMID 17898169Read ↗

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma.Semantic proximity Read ↗

Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control.Semantic proximity Read ↗

Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease.Semantic proximity Read ↗

Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthmaSemantic proximity Read ↗

Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in AsthmaSemantic proximity Read ↗

Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cellsSemantic proximity Read ↗

Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line.Semantic proximity Read ↗

Consistent Biomarkers and Related Pathogenesis Underlying Asthma Revealed by Systems Biology ApproachSemantic proximity Read ↗

The effects of inhaled corticosteroids on healthy airwaysSemantic proximity Read ↗

Identification of Novel Genes in Human Airway Epithelial Cells associated with Chronic Obstructive Pulmonary Disease (COPD) using Machine-Based Learning AlgorithmsSemantic proximity Read ↗

Airway epithelial cell cilia transcriptomic dysregulation is associated with the inflammatory phenotype in asthmaSemantic proximity Read ↗

BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of MedicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.